No. 14 Pine Creek vs. No. 3 Mountain Vista
When: Friday, 6:30 p.m.
Where: At Shea Stadium, Highlands Ranch
What to know: These teams know each other well. Mountain Vista (13-2-1), last year's state runner-up, beat the Eagles 4-2 earlier this month. The Golden Eagles also won last season, while Pine Creek (12-4) won in 2015 and 2014. The Eagles are on a three-game winning streak, while Mountain Vista has won 11 in a row, unbeaten since March 28. Katie Joella leads the Golden Eagles with 13 goals and Katie Harris has 12. Natasha Wehner's 13 goals lead Pine Creek, while Madeline Alhamra has 11.
No. 19 Littleton vs. No. 3 Lewis-Palmer
When: Saturday, 11 a.m.
Where: At Lewis-Palmer
What to know: The 4A defending champion Rangers (14-2) blew out Elizabeth 9-1 in the first round, a strong response after getting blanked 4-0 by 5A Ralston Valley in the regular-season finale. Littleton (8-8) cruised past Holy Family 5-1. Bri Alger led the Rangers with 19 goals and seven assists in the regular season. Sarah Payson and Sarah Gray each have 12 goals for the Lions, who have won four straight.
No. 11 Cheyenne Mountain vs. No. 6 Windsor
When: Saturday, 6:30 p.m.
Where: At Windsor
What to know: This year has been one for powerhouse Cheyenne Mountain (9-6) to rely on its defense. The Indians did that again on Wednesday when they blanked Eagle Valley in the first round, the Indians third straight shutout and fourth straight win. Windsor (15-1), a semifinalist a season ago, eliminated Cheyenne Mountain in last year's playoffs. The Wizards opened the postseason with a 5-0 win over Northridge. If the Indians can pull off the upset, they would likely get league rival Lewis-Palmer in the quarterfinals. Abby Gearhart and Margaret Zimmerman have combined for 56 goals for the Wizards - Gearhart with 31. The Indians have scored 45 goals this season, led by Lisa Long's nine.
No. 12 Air Academy vs. No. 5 TCA
When: Saturday, 7 p.m.
Where: The Classical Academy
What to know: There might be one out there, but it's tough finding a better second-round game than this one. TCA (14-1) defeated Air Academy 1-0 way back on March 14, during the Titans 13-game winning streak. TCA eliminated Green Mountain 4-0 in the first round, while the Kadets (11-5), held off Skyline 2-1. Air Academy reeled off six straight wins before falling to Windsor last week. The Kadets are led by Lily Tiefel's nine goals, one of 13 goal scorers for the team. TCA, which coasted to the 4A CSML crown, is second in the state regardless of classification with 101 goals. Hannah Burgo leads the Titans and is second in 4A with 32 goals.
No. 19 Basalt/No. 14 Salida vs. No. 3 Manitou Springs
When: Saturday, 1 p.m.
Where: At Manitou Springs
What to know: As a host, Manitou Springs (14-1) will have to wait an extra day before starting its playoff journey. The Mustangs will be able to scout Basalt (11-4) and Salida (10-5) on Friday before hosting that winner. Brooklyn Mack scored 28 goals to lead the Mustangs and Bridget Bodor added 15 and 11 assists. Manitou gave up six goals all season. Two of those were to No. 1 Jefferson Academy, which the Mustangs wouldn't face until the final.
No. 24 KIPP Denver/No. 9 SkyView Academy vs. No. 8 CSCS
When: Saturday, 3 p.m.
Where: At UCCS Stadium
What to know: A week ago, SkyView Academy (10-4-1) beat CSCS (12-3) in overtime. Yet the Lions are ranked one spot ahead of Skyview and that spot made all the difference with CSCS getting to host. The Lions will await the winner between KIPP Denver Collegiate (11-4) and SkyView before opening the postseason. They've dropped two of their last five games - to SkyView and No. 20 Lutheran. Gabby Huthoefer's 33 goals lead the Lions.
No. 20 Lutheran vs. No. 13 St. Mary's
When: Friday, 4 p.m.
Where: At Fossil Ridge High School
What to know: St. Mary's (11-4) hits the road for the first round. The Pirates get a sub-.500 opponent in Lutheran (7-8). Freshman Calli Haney led the Lions with seven goals. The Pirates have six players who scored more than seven goals, led by Faith Heery's 16. The winner will play No. 4 Liberty Common at Fossil Ridge on Saturday at 1 p.m.
No. 18 Florence vs. No. 15 Vail Mountain
When: Friday, 4 p.m.
Where: At Colorado Academy
What to know: Florence (10-4-1) is undefeated in its last four games (3-0-1) and has just one loss over its last seven since a three-game losing streak in mid April. Junior Rysa Lancaster leads the Huskies with 28 goals. Vail has dropped two of its last five. The team has no individual stats listed. Friday's winner will play at No. 2 Colorado Academy (11-3-1) on Saturday at 11 a.m. Colorado Academy lost in last year's championship game.
No. 5 Fountain Valley vs. No. 4 ECA
When: Friday, 7:30 p.m.
Where: El Pomar Olin Field
What to know: In another curious case of the RPI, Fountain Valley (11-5) went unbeaten on its way to winning the 2A Region 1 title, beat ECA head to head and notched three more wins than the Eagles (8-5-1). Yet ECA will host this league rivalry quarterfinal and had a first-round bye. The Danes took a 3-0 first-half lead and rode it to a 5-3 win over ECA on May 4. They also blew out No. 12 Heritage Christian 8-1 in the first round. McKenna Monk's 40 goals lead the Danes (and all of 2A), while April Mann leads ECA with 15.